The generally consensus seems to be, especially with movies, that remakes/reboots are bad. The past was awesome, the present is mostly crap. Be that as it may, if you have unlimited resources, which game would you like to bring back? Which studio should make it? But most of all, what must it be like?
For me, it's Blood. The very best of the Build engine games. Extremely violent, dark and the coolest weapons and one liners ever. Playing soccer with decapitated heads? Check! Burning people with a flare gun or spray can? Check! Stabbing people to death with a voodoo doll? Check! Not sure which studio should bring it back though. The most important thing would be to maintain the original look and feel. Preferably the pixel porn. It's a game that simple doesn't need a whole lot more.
Should you have missed out on this legendary piece of software, you can buy it for almost nothing on Gog.com.
http://www.gog.com/game/one_unit_whole_blood
Of course, a image says more then a thousand words, so enjoy this Youtube video:
Now it's your turn!
PS: I forget to mention the game's incredible enemies like the cut of hand from Evil Dead, that keeps choking you while screaming "I'll swallow your soul".