360 and Wii are actually way easier to mod than last gen, both can be done easy with softmodding. I was still hearing about people having to sauter (however you spell it) in custom chips to pirate Xbox games way late into that console's life.
Now, on the Wii, running pirate games is as easy as an SD card, some programs you can download for free on the internet, and a HD to stick the games on.
PC pirate numbers get hugely inflated by non-customers, people in non-markets who the game's not even being sold to, teenagers, etc.
I really think, in terms of real profit potential, not straight retail sales figures or sales vs pirates copies or anything, just straight up money spent vs money made, I gotta listen to the Stardock, Paradox, and Valve guys. PC's worldwide appeal and the internet's cheap and easy, long-lasting, widespread availability means PC games have MORE potential, not less.
Sims 2 sold more copies on PC alone, only counting retail, than Modern Warfare did on every platform, plus those dozens of expansion packs and "stuff packs" ![]()
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Edit: Hell, Half-life 2 probably did too, it sold 6.5 mil copies but that's not counting Steam or the orange box.